Yurii V. Soroka, Nataliya P. Zykova, Nina O. Zahurska, Оlha M. Zahurska, Oleksandr L. Filenko О, Iryna Ya. Andriichuk, Zoya M. Nebesna, Nataliya Ye. Lisnychuk
Molecular-genetic study of the Bcl-2 C938A gene polymorphism in patients with colorectal cancer in age and gender aspects. Blood samples of 48 patients were tested for the presence of the Bcl-2 C938A gene polymorphism using the AC-PCR method. The genotype and allele frequency of Bcl-2 SNP (-938C>A) were statistically analyzed. The predominance of the heterozygous variant of the CA genotype was established in both men and women diagnosed with colon adenocarcinoma. The homozygous variant of the СС genotype did not have statistically significant difference in the comparison groups. In a group of practically healthy women, a homozygous variant of the AA genotype was detected with a frequency of 80.0%. The heterozygous variant of the CA genotype of the C938A polymorphic variant of the Bcl-2 gene is statistically significantly associated with colon cancer in both men and women. Determination of Bcl-2 gene polymorphism at position 938 can become a marker for early diagnosis of colorectal cancer and can also be a promising criterion for assessing the risk of neoplastic lesions of the colon.
