Anastasiia Olehivna Radchenko, Olena Vadymivna Kolesnikova
Arterial hypertension (AH) and subclinical hypothyroidism (SH) are a common example of comorbid diseases. They share common cardiovascular risk factors, among which genetic factors are the least studied, albeit no less important. The aim of our study was to evaluate the role of SOD2 (rs4880) and SIRT1 (rs7069102) polymorphisms as determinants of the development of cardiometabolic disorders among patients with AH depending on the presence of SH. The study included 79 patients with stage I-II grade 1-2 AH with a median age of 49.4 [41.4;55.1] (women 63%), who were divided into 2 groups depending on the presence of SH . The study presents the distribution of genotypes and alleles of the investigated polymorphisms, as well as the levels of cardiometabolic indicators in patients of different groups depending on the polymorphic gene variant. According to our study carriers of the G allele of the SIRT1 gene and the C allele of the SOD2 gene with a combined course of AH and SH have higher levels of insulin (p=0.021), homeostatic model assessment for insulin resistance (p=0.012), glycosylated hemoglobin (p=0.000), total cholesterol (p= 0.049), non-high-density lipoprotein cholesterol (p=0.026), very low-density lipoprotein cholesterol (p=0.036), C-reactive protein (p-0.000) and tumor necrosis factor alpha (p=0.000), as well as a higher frequency of elevated alanine aminotransferase levels (p=0.012), insulin (p=0.027) and C-reactive protein (p=0.017) compared to euthyroid patients with similar genotypes.
